Synthesis and in vitro cytotoxicity evaluation of β-carboline-linked 2,4-thiazolidinedione hybrids: potential DNA intercalation and apoptosis-inducing studies-Reference-Cited by-同舟云学术

Synthesis and in vitro cytotoxicity evaluation of β-carboline-linked 2,4-thiazolidinedione hybrids: potential DNA intercalation and apoptosis-inducing studies

Published:2018 Issue:19 Volume:42 Page:16226-16236
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Tokala Ramya¹²³,Thatikonda Sowjanya⁴²³,Sana Sravani¹²³,Regur Phanindranath⁵⁶³,Godugu Chandraiah⁴²³,Shankaraiah Nagula¹²³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER)

2. Hyderabad-500037

3. India

4. Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)

5. CSIR-Centre for Cellular and Molecular Biology

6. Hyderabad-500007

Abstract

A series of β-carboline-linked 2,4-thiazolidinedione hybrids was synthesized and studied for their DNA affinities and cytotoxicities. The most potent compound was 19e with IC₅₀ of 0.97 ± 0.13 μM.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NJ/C8NJ03248C

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