A ‘catch-and-release’ receptor for the cholera toxin-Reference-Cited by-同舟云学术

A ‘catch-and-release’ receptor for the cholera toxin

Published:2019 Issue: Volume:219 Page:112-127
ISSN:1359-6640
Container-title:Faraday Discussions
language:en
Short-container-title:Faraday Discuss.

Author:

Mahon Clare S.¹²³⁴⁵,Wildsmith Gemma C.¹²³⁴,Haksar Diksha⁶⁷⁸⁹¹⁰,de Poel Eyleen¹¹¹²¹³⁹¹⁰,Beekman Jeffrey M.¹¹¹²¹³⁹¹⁰,Pieters Roland J.⁶⁷⁸⁹¹⁰,Webb Michael E.¹²³⁴,Turnbull W. Bruce¹²³⁴⁵

Affiliation:

1. School of Chemistry and Astbury Centre for Structural Molecular Biology

2. University of Leeds

3. Leeds

4. UK

5. Department of Chemistry

6. Department of Chemical Biology & Drug Discovery

7. Utrecht Institute for Pharmaceutical Sciences

8. Utrecht University

9. Utrecht

10. The Netherlands

11. Department of Pediatric Pulmonology

12. Wilhelmina Children’s Hospital and Regenerative Medicine Center Utrecht

13. University Medical Centre Utrecht

Abstract

Thermoresponsive receptors for the recognition unit of the cholera toxin (CTB) can recognise the protein with nanomolar affinity. An increase in temperature can drastically reduce their avidity, enabling on-demand release of CTB.

Funder

Engineering and Physical Sciences Research Council

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FD/C9FD00017H

Reference39 articles.

1. Modulators of Protein–Protein Interactions

2. Strategies for Targeting Protein-Protein Interactions With Synthetic Agents