Synthesis of cRGD peptide cluster-decorated NIR-fluorescent PISA-RAFT nanoparticles targeting integrin expressing cells

Author:

Duret Damien1,Grassin Adrien2,Henry Maxime3,Alcouffe Pierre1,Raja Sebastian4ORCID,Baleizão Carlos4ORCID,Farinha José Paulo4ORCID,Charreyre Marie-Thérèse1,Boturyn Didier2ORCID,Coll Jean-Luc3ORCID,Favier Arnaud1ORCID

Affiliation:

1. Université de Lyon, CNRS, Université Lyon 1, INSA Lyon, Université Jean Monnet, UMR 5223, Ingénierie des Matériaux Polymères, F-69621 Villeurbanne, France

2. University Grenoble Alpes, CNRS, UMR 5250, Department of Molecular Chemistry, 38000 Grenoble, France

3. University Grenoble Alpes, Institute for Advanced Biosciences, Team Cancer Targets and Experimental Therapeutics, INSERM U1209, CNRS UMR5309, Grenoble 38100, France

4. Centro de Química Estrutural, Institute of Molecular Sciences and Department of Chemical Engineering, Instituto Superior Técnico, University of Lisbon, P-1049-001 Lisbon, Portugal

Abstract

Biocompatible PISA-RAFT nanoparticles were synthesized with NIR-fluorescent monomers in the core and cRGD peptide clusters at the outer surface. These original nanoprobes selectively labeled integrin-presenting cells.

Funder

Institut National de la Santé et de la Recherche Médicale

Ligue Contre le Cancer

Agence Nationale de la Recherche

Campus France

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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