Re-engineering of PIP3-antagonist triazole PITENIN's chemical scaffold: development of novel antifungal leads-Reference-Cited by-同舟云学术

Re-engineering of PIP3-antagonist triazole PITENIN's chemical scaffold: development of novel antifungal leads

Published:2016 Issue:14 Volume:6 Page:11691-11701
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pulya Sravani¹²³⁴,Kommagalla Yadagiri¹²³⁴,Sant Duhita G.⁵²³⁴,Jorwekar Shweta U.⁵²³⁴,Tupe Santosh G.⁵²³⁴,Deshpande Mukund V.⁵²³⁴,Ramana Chepuri V.¹²³⁴

Affiliation:

1. Division of Organic Chemistry

2. CSIR-National Chemical Laboratory

3. Pune-411008

4. India

5. Biochemical Sciences Division

Abstract

A novel 4-(1-phenyl-1-hydroxyethyl)-1-(o-hydroxyphenyl)-1H-1,2,3-triazole was designed by integrating the structural features of triazole PITENIN anticancer agents and the azole class of antifungal drugs.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA25145A

Reference63 articles.

1. Novel Antifungal Drugs Against Fungal Pathogens: Do They Provide Promising Results for Treatment?

2. In vitro interaction of posaconazole with calcineurin inhibitors and sirolimus against zygomycetes

3. Rationally Designed Transmembrane Peptide Mimics of the Multidrug Transporter Protein Cdr1 Act as Antagonists to Selectively Block Drug Efflux and Chemosensitize Azole-resistant Clinical Isolates of Candida albicans

4. Synthesis and antimicrobial activity of 4-phenyl/cyclohexyl-5-(1-phenoxyethyl)-3-[N-(2-thiazolyl)acetamido]thio-4H-1,2,4-triazole derivatives

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