2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway-Reference-Cited by-同舟云学术

2,5-Hexanedione induces autophagic death of VSC4.1 cells via a PI3K/Akt/mTOR pathway

Published:2017 Issue:10 Volume:13 Page:1993-2005
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Guan Huai¹²^ORCID,Piao Hua³⁴⁵²^ORCID,Qian Zhiqiang⁶⁴⁵²^ORCID,Zhou Xueying⁶⁴⁵²^ORCID,Sun Yijie⁶⁴⁵²^ORCID,Gao Chenxue⁶⁴⁵²^ORCID,Li Shuangyue⁶⁴⁵²^ORCID,Piao Fengyuan⁶⁴⁵²^ORCID

Affiliation:

1. Department of Obstetrics and Gynecology

2. China

3. Department of Physiology

4. Dalian Medical University

5. Dalian 116044

6. Department of Occupational and Environmental Health

Abstract

2,5-Hexanedione (HD) is an important bioactive metabolite ofn-hexane, which mediates the neurotoxicity of the parent compound.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MB/C7MB00001D

Reference57 articles.

1. n-Hexane and its toxicologic effects – a review

2. Toxicity and Metabolism of the Neurotoxic Hexacarbons n-Hexane, 2-Hexanone, and 2,5-Hexanedione

3. Autophagy for tissue homeostasis and neuroprotection

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