A study of complexation and biological fate of polyethyleneimine-siRNA polyplexes <i>in vitro</i> and <i>in vivo</i> by fluorescence correlation spectroscopy and positron emission tomography imaging-Reference-Cited by-同舟云学术

A study of complexation and biological fate of polyethyleneimine-siRNA polyplexes in vitro and in vivo by fluorescence correlation spectroscopy and positron emission tomography imaging

Published:2024 Issue:7 Volume:16 Page:3525-3533
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Ludtke Tanja¹,Simó Cristina¹²^ORCID,Gimenez Reyes Santiago¹³,Martinez Moro Marta¹,Salvador Cristian⁴,Ritacco Hernan³^ORCID,Andreozzi Patrizia⁵,Llop Jordi²^ORCID,Moya Sergio E.¹^ORCID

Affiliation:

1. Soft Matter Nanotechnology, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014, Donostia-San Sebastián, Spain

2. Radiochemistry and Nuclear Imaging laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014, Donostia-San Sebastián, Spain

3. Instituto de Fisica del Sur (IFISUR-CONICET), Av. Alem, Bahia Blanca, Argentina

4. CIDETEC, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Gipuzkoa, Miramon Pasealekua, 196, Donostia-San Sebastián 20014, Spain

5. Department of Chemistry ‘Ugo Schiff’, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, FI, Italy

Abstract

Fluorescence correlation spectroscopy and positron emission tomography are used to study the formation of PEI siRNA polyplex nanoparticles and to trace their biological fate at cell level and in vivo.

Funder

Ministerio de Ciencia e Innovación

Ministero dell’Istruzione, dell’Università e della Ricerca

Agencia Estatal de Investigación

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D3NR04026G

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