Quantitative assessment of daratumumab in serum <i>via</i> intact light chain measurement using liquid chromatography-high resolution mass spectrometry: a method suitable for therapeutic drug monitoring-Reference-Cited by-同舟云学术

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Quantitative assessment of daratumumab in serum via intact light chain measurement using liquid chromatography-high resolution mass spectrometry: a method suitable for therapeutic drug monitoring

Published:2024 Issue:26 Volume:16 Page:4240-4246
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Canil Giovanni¹^ORCID,Miolo Gianmaria²,Simula Mariapaola³,Rupolo Maurizio⁴,Steffan Agostino¹,Corona Giuseppe¹^ORCID

Affiliation:

1. Immunopathology and Cancer Biomarkers Unit, Centro di Riferimento Oncologico (CRO), IRCCS Aviano, 33081 Aviano, Italy

2. Medical Oncology and Cancer Prevention Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy

3. Clinical Pathology Unit, ASFO General Hospital, 33170 Pordenone, Italy

4. Oncohematology and Cell Therapy Unit, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, 33081 Aviano, Italy

Abstract

Effective quantification of serum daratumumab monoclonal antibody for therapeutic drug monitoring using LC-HRMS based on light chain analysis.

Funder

Ministero della Salute

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AY/D4AY00404C

Reference22 articles.

1. Daratumumab: First Global Approval

2. Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma

3. Pharmacokinetics of Daratumumab Following Intravenous Infusion in Relapsed or Refractory Multiple Myeloma After Prior Proteasome Inhibitor and Immunomodulatory Drug Treatment

4. Clinical Pharmacokinetics and Pharmacodynamics of Daratumumab

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