N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

Published:2021 Issue:10 Volume:12 Page:1698-1708
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Yahiaoui Samir¹^ORCID,Voos Katrin²^ORCID,Haupenthal Jörg¹^ORCID,Wichelhaus Thomas A.³,Frank Denia³^ORCID,Weizel Lilia⁴,Rotter Marco⁴,Brunst Steffen⁴,Kramer Jan S.⁴^ORCID,Proschak Ewgenij⁴,Ducho Christian²^ORCID,Hirsch Anna K. H.¹⁵^ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) – Helmholtz Centre for Infection Research (HZI), Campus E8 1, 66123 Saarbrücken, Germany

2. Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2 3, 66123 Saarbrücken, Germany

3. Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Paul-Ehrlich-Straße 40, 60596 Frankfurt, Germany

4. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Straße 9, 60438, Frankfurt, Germany

5. Department of Pharmacy, Saarland University, Campus Building E8 1, 66123 Saarbrücken, Germany

Abstract

Simultaneous inhibition of metallo-β-lactamases (MBLs) and virulence factors such as LasB from Pseudomonas aeruginosa offers a new approach to combat antibiotic-resistant pathogens.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00187F

Reference74 articles.

1. World Health Organization , Antibacterial Agents in Clinical Development, in An Analysis of the Antibacterial Clinical Development Pipeline, Including Tuberculosis , The World Health Organization , Geneva , 2017

2. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment

3. Understanding the control of Pseudomonas aeruginosa alginate synthesis and the prospects for management of chronic infections in cystic fibrosis

4. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

5. How to manage Pseudomonas aeruginosa infections

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose;European Journal of Medicinal Chemistry;2024-02

2. Design, Synthesis and Antibacterial Activity Evaluation of Ebselen Derivatives as NDM-1 Inhibitors;2024

3. Immunomodulatory role of metalloproteinase ADAM17 in tumor development;Frontiers in Immunology;2022-11-17

4. Recent advances in β-lactamase inhibitor chemotypes and inhibition modes;European Journal of Medicinal Chemistry;2022-11

5. Recent Developments to Cope the Antibacterial Resistance via β-Lactamase Inhibition;Molecules;2022-06-14