A novel cyanoacrylate-based matrix excipient in HPMCP capsules forms a sustained intestinal delivery system for orally administered drugs with enhanced absorption efficiency

Author:

Song Liya12345,Chen Pengfei67894,Yu Jin10894,Han Xiaolu1234,Hua Yabing1234,Liu Shan11124,Pang Bo131415164,Gao Jing1234,Ma Jiahua517184,Xu Liang1234ORCID

Affiliation:

1. State Key Laboratory of Toxicology and Medical Countermeasures

2. Beijing Institute of Pharmacology and Toxicology

3. Beijing

4. China

5. School of Life Science and Engineering

6. Department of Cardiology

7. the 6th Medical Center

8. Chinese PLA General Hospital

9. Beijing 100853

10. Department of Neurology (the First Medical Center)

11. Pathology Department of PLA Rocket Force Characteristic Medical Center

12. Beijing 100085

13. Clinical Laboratory

14. Guanganmen Hospital

15. China Academy of Chinese Medical Science

16. Beijing 100053

17. Southwest University of Science and Technology

18. Mianyang 621010

Abstract

ASA–polyMECA–HPMCP could improve drug bioavailability.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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