Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model-Reference-Cited by-同舟云学术

Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model

Published:2023 Issue:10 Volume:23 Page:2434-2446
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

González-Lana Sandra¹²^ORCID,Randelovic Teodora¹³⁴,Ciriza Jesús¹³^ORCID,López-Valdeolivas María⁵,Monge Rosa²,Sánchez-Somolinos Carlos⁴⁵^ORCID,Ochoa Ignacio¹³⁴^ORCID

Affiliation:

1. Tissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, C/ Mariano Esquillor s/n, 500018 Zaragoza, Spain

2. BEONCHIP S.L., CEMINEM, Campus Río Ebro. C/ Mariano Esquillor Gómez s/n, 50018 Zaragoza, Spain

3. Institute for Health Research Aragón (IIS Aragón), Paseo de Isabel La Católica 1-3, 50009 Zaragoza, Spain

4. CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain

5. Aragón Institute of Nanoscience and Materials (INMA), Department of Condensed Matter Physics (Faculty of Science), CSIC-University of Zaragoza, C/ Pedro Cerbuna 12, 50009 Zaragoza, Spain

Abstract

Study explores COP-based microfluidic device surface modifications to maintain 3D cell culture, prevent hydrogel detachment and enable more accuratein vitromodels mimicking tumour microenvironment and ischaemia.

Funder

Horizon 2020 Framework Programme

H2020 Marie Skłodowska-Curie Actions

Spanish National Plan for Scientific and Technical Research and Innovation

Key Digital Technologies Joint Undertaking

European Social Fund

Agencia Estatal de Investigación

Centre for Industrial Technological Development

Gobierno de Aragón

Instituto de Salud Carlos III

Publisher

Royal Society of Chemistry (RSC)