Asymmetric bifunctional protein nanoparticles through redesign of self-assembly-Reference-Cited by-同舟云学术

Asymmetric bifunctional protein nanoparticles through redesign of self-assembly

Published:2019 Issue:5 Volume:1 Page:1833-1846
ISSN:2516-0230
Container-title:Nanoscale Advances
language:en
Short-container-title:Nanoscale Adv.

Author:

Sosa Santiago¹²³⁴³,Rossi Andrés H.¹²³,Szalai Alan M.⁴³,Klinke Sebastián¹²³⁵³^ORCID,Rinaldi Jimena¹²³,Farias Ana¹²³,Berguer Paula M.¹²³,Nadra Alejandro D.⁶⁷⁸⁹¹⁰^ORCID,Stefani Fernando D.⁴³¹¹⁹¹⁰^ORCID,Goldbaum Fernando A.¹²³⁵³,Bonomi Hernán R.¹²³^ORCID

Affiliation:

1. Fundación Instituto Leloir

2. IIBBA-CONICET

3. Argentina

4. Centro de Investigaciones en Bionanociencias (CIBION)-CONICET

5. Plataforma Argentina de Biología Estructural y Metabolómica PLABEM

6. Departamento de Fisiología

7. Biología Molecular y Celular

8. Departamento de Química Biológica and IQUIBICEN-CONICET

9. Facultad de Ciencias Exactas y Naturales

10. Universidad de Buenos Aires

11. Departamento de Física

Abstract

In this work we rationally redesign and engineer a decameric protein scaffold to generate an asymmetric Janus-like protein nanoparticle. As a proof of concept this novel scaffold is functionalized (i) to fluorescently label eukaryotic cells and (ii) to generate a multichromophoric FRET nanoparticle.

Funder

Fondo para la Investigación Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NA/C8NA00375K

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2. Tuning Viral Capsid Nanoparticle Stability with Symmetrical Morphogenesis

3. How Oligomerization Contributes to the Thermostability of an Archaeon Protein