A photocleavable peptide-tagged mass probe for chemical mapping of epidermal growth factor receptor 2 (HER2) in human cancer cells

Author:

Liu Liang12345,Kuang Yuqiong12345,Wang Zhongcheng1234,Chen Yun12346ORCID

Affiliation:

1. School of Pharmacy

2. Nanjing Medical University

3. Nanjing

4. China

5. Department of Pharmacy

6. State Key Laboratory of Reproductive Medicine

Abstract

An integrated approach based on a photocleavable peptide tagged mass probe provides chemical mapping including quantitative and visual information of HER2.

Funder

National Natural Science Foundation of China

Southeast University

Nanjing Medical University

China Pharmaceutical University

Jiangsu Provincial Key Research and Development Program

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Reference43 articles.

1. HER2: Biology, Detection, and Clinical Implications

2. FDA-NIH Biomarker Working Group , BEST (biomarkers, Endpoints, and other tools) Resource , Food and Drug Administration (US) , Silver Spring (MD) , 2016 , accessed August 10, 2020, http://www.ncbi.nlm.nih.gov/books/NBK326791/

3. Induction of targeted necrosis with HER2-targeted platinum(iv) anticancer prodrugs

4. Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly

5. Advances in HER2 testing

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