Insight into the synthesis of N-methylated polypeptides
Author:
Affiliation:
1. Department of Chemistry
2. Johannes Gutenberg University Mainz
3. 55099 Mainz
4. Germany
5. Leiden Academic Center for Drug Research (LACDR)
Abstract
The ring-opening polymerization of α-substituted N-methylated N-carboxy anhydrides is reported. The polymerization was tested using various amino acids and initiators, and was found to be limited by the steric demand of N-methylated compared to conventional amino acids.
Funder
European Commission
Evonik Stiftung
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering
Link
http://pubs.rsc.org/en/content/articlepdf/2020/PY/D0PY01055C
Reference41 articles.
1. N-Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions
2. N-methylation in amino acids and peptides: Scope and limitations
3. Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues
4. In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Aβ aggregation
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