Small-artery-mimicking multi-layered 3D co-culture in a self-folding porous graphene-based film

Author:

Sakai Koji1ORCID,Miura Shigenori2ORCID,Teshima Tetsuhiko F.3ORCID,Goto Toichiro1,Takeuchi Shoji245ORCID,Yamaguchi Masumi1

Affiliation:

1. NTT Basic Research Laboratories and Bio-Medical Informatics Research Center, NTT Corporation, 3-1 Morinosato Wakamiya, Atsugi, Kanagawa, 243-0198, Japan

2. Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan

3. Medical and Health Informatics Laboratories, NTT Research Incorporated, 940 Stewart Dr, Sunnyvale, CA, 94085, USA

4. Department of Mechano-Informatics, Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

5. International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract

We co-cultured endothelial and smooth muscle cells in a self-folding porous film to create a vessel-like in vitro model. The tunability of the geometries including curvature and pore size enables us to emulate the geometries of a small artery.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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