Access to 3,3-disubstituted oxindoles via microwave-assisted Cannizzaro and aldol reactions of formaldehyde with isatins and their imines-Reference-Cited by-同舟云学术

Access to 3,3-disubstituted oxindoles via microwave-assisted Cannizzaro and aldol reactions of formaldehyde with isatins and their imines

Published:2021 Issue:28 Volume:11 Page:17320-17323
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Huang Xuan¹²³⁴⁵,Wang Hongling¹²³⁴⁵,Cao Qingxiang¹²³⁴⁵,Li Yong¹²³⁴⁵,Zhang Junmin¹²³⁴⁵^ORCID

Affiliation:

1. International Joint Research Centre for Molecular Science

2. College of Chemistry and Environmental Engineering

3. Shenzhen University

4. Shenzhen

5. P. R. China

Abstract

The reaction proceeds with the assistance of microwave heating in a mild base. Formaldehyde behaves as both a reductant (via a Cannizzaro process with isatin) and an electrophile.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Department of Education of Guangdong Province

Shenzhen University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA02150H

Reference34 articles.

1. Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles

2. Tandem Radical Cyclization of N-Arylacrylamides: An Emerging Platform for the Construction of 3,3-Disubstituted Oxindoles

3. A.Moyano and X.Companyò , Catalytic asymmetric strategies for the synthesis of 3,3-disubstituted oxindoles , Studies in Natural Products Chemistry , 2013 , ch. 4, vol. 40 , pp. 71–132

4. Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthetic applications of the Cannizzaro reaction;Beilstein Journal of Organic Chemistry;2024-06-19

2. Stereoelectronic Effect in the Reaction of α-Methylene Lactones with Tertiary Phosphines and Its Application in Organocatalysis;The Journal of Organic Chemistry;2023-08-04

3. Rongalite-induced transition-metal and hydride-free reductive aldol reaction: a rapid access to 3,3′-disubstituted oxindoles and its mechanistic studies;Organic & Biomolecular Chemistry;2022