Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana-Reference-Cited by-同舟云学术

Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,8′-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana

Published:2019 Issue:21 Volume:9 Page:12034-12046
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mufusama Jean-Pierre¹²³⁴⁵,Feineis Doris¹²³⁴,Mudogo Virima⁶⁷⁸,Kaiser Marcel⁹¹⁰¹¹¹²¹³,Brun Reto⁹¹⁰¹¹¹²¹³,Bringmann Gerhard¹²³⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry

2. University of Würzburg

3. D-97074 Würzburg

4. Germany

5. Faculté des Sciences Pharmaceutiques

6. Faculté des Sciences

7. Université de Kinshasa

8. Democratic Republic of the Congo

9. Swiss Tropical and Public Health Institute

10. CH-4002 Basel

11. Switzerland

12. University of Basel

13. CH-4003 Basel

Abstract

The discovery of the two unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, the mbandakamines B₃ and B₄, showing a high steric hindrance at the central biaryl axis and displaying pronounced antiplasmodial activities, is described.

Funder

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA01784D

Reference51 articles.

1. A Synoptic Revision of Ancistrocladus (Ancistrocladaceae) in Africa, with a New Species from Western Cameroon

2. Microsatellites facilitate species delimitation in Congolese Ancistrocladus (Ancistrocladaceae), a genus with pharmacologically potent naphthylisoquinoline alkaloids