Convenient synthesis and X-ray determination of 2-amino-6H-1,3,4-thiadiazin-3-ium bromides endowed with antiproliferative activity

Author:

Tawfeek Hendawy N.12,Abdelmoez Alshaimaa34,Dahlous Kholood A.5,Youssif Bahaa G. M.3ORCID,Bräse Stefan6ORCID,Rissanen Kari7ORCID,Nieger Martin8,El-Sheref Essmat M.1

Affiliation:

1. Chemistry Department, Faculty of Science, Minia University, El Minia, 61519 Egypt

2. Unit of Occupational of Safety and Health, Administration Office of Minia University, El-Minia 61519, Egypt

3. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

4. Department of Neurology, Ulm University, Ulm, Germany

5. Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia

6. Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany

7. Department of Chemistry, University of Jyväskylä, PO Box 35, 40014 Jyväskylä, Finland

8. Department of Chemistry, University of Helsinki, PO Box 55, A. I. Virtasen Aukio 1, 00014 Helsinki, Finland

Abstract

A series of new 1,3,4-thiadiazine bromide derivatives was developed as antiproliferative agents targeting EGFR, BRAFV600E, and VEGFR-2.

Funder

Karlsruhe Institute of Technology

King Saud University

Publisher

Royal Society of Chemistry (RSC)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3