Dietary <i>Lactobacillus rhamnosus</i> GG extracellular vesicles enhance antiprogrammed cell death 1 (anti-PD-1) immunotherapy efficacy against colorectal cancer-Reference-Cited by-同舟云学术

Dietary Lactobacillus rhamnosus GG extracellular vesicles enhance antiprogrammed cell death 1 (anti-PD-1) immunotherapy efficacy against colorectal cancer

Published:2023 Issue:23 Volume:14 Page:10314-10328
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Lu Shun¹,Xu Jing¹,Zhao Zihao¹,Guo Yuheng¹,Zhang Hanwen¹,Jurutka Peter W.²^ORCID,Huang Dechun³,Cao Chongjiang¹^ORCID,Cheng Shujie¹^ORCID

Affiliation:

1. Department of Food Nutrition and Safety, School of Engineering, China Pharmaceutical University, Nanjing 211198, P. R. China

2. School of Mathematical and Natural Sciences, Arizona State University, AZ 85306, USA

3. Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, P. R. China

Abstract

Dietary Lactobacillus rhamnosus GG extracellular vesicles (LGG-EV) synergistically enhanced anti-PD-1 immunotherapy efficacy against colorectal cancer. It was associated with improved tumor immunosuppressive environment, the abundance of beneficial bacteria and elevated specific serum metabolites.

Funder

National Key Research and Development Program of China

Key Technology Research and Development Program of Shandong

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/FO/D3FO02018E

Reference56 articles.

1. Regulatory circuits of T cell function in cancer

2. Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer