Citrus peel extract protects against diesel exhaust particle-induced chronic obstructive pulmonary disease-like lung lesions and oxidative stress

Author:

Fang Zhang-fu123ORCID,Fu Yu3,Peng Yang3,Song Sheng-ren4,Wang Zhao-ni3,Yang Yang3,Nie Yi-chu5,Han Hai-long6,Teng Yan-bo6,Xiao Wei-min7,Chen Jia-ping7,Zhou Bao-jin8,Ou Guo-liang9,Xie Jia-xing3,Liu Xiao-yu10,Zhang Junfeng (Jim)116,Zhong Nan-shan23

Affiliation:

1. Department of Respirology & Allergy, Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China

2. Guangzhou Laboratory, Guangzhou 510320, China

3. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

4. Department of Respiratory Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China

5. Translational Medicine Research Institute, First People's Hospital of Foshan, Foshan, Guangdong, 528000, China

6. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu 215316, China

7. Shenzhen Academy of Metrology & Quality Inspection, Shenzhen 518055, China

8. Deepxomics-Shenzhen, Shenzhen 518083, China

9. Jiangmen Palace International Food, Inc., Jiangmen 529000, China

10. State Key Laboratory of Respiratory Disease Allergy Division at Shenzhen University, Institute of Allergy & Immunology, Shenzhen University School of Medicine, Shenzhen 518061, China

11. Nicholas School of the Environment and Global Health Institute, Duke University, Durham, North Carolina 27708, USA

Abstract

This study revealed for the first time that citrus peel extract (GC) is effective in decreasing oxidative stress and inflammatory responses of the peripheral lungs to DEP exposure, thus leading to the resolution of COPD-like lesions.

Funder

State Key Laboratory of Respiratory Disease

Shenzhen Fundamental Research Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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