Chiral auxiliary recycling in continuous flow: automated recovery and reuse of Oppolzer's sultam-Reference-Cited by-同舟云学术

Chiral auxiliary recycling in continuous flow: automated recovery and reuse of Oppolzer's sultam

Published:2018 Issue:8 Volume:9 Page:2130-2134
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sullivan R. J.¹²³⁴⁵^ORCID,Newman S. G.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Catalysis Research and Innovation

2. Department of Chemistry and Biomolecular Sciences

3. University of Ottawa

4. Ottawa

5. Canada

Abstract

The telescoping of a three-stage, chiral auxiliary-mediated transformation in flow is described, including continuous separation of the product and auxiliary, enabling automated auxiliary reuse.

Funder

Natural Sciences and Engineering Research Council of Canada

University of Ottawa

Canadian Foundation for Innovation

Ontario Ministry of Economic Development and Innovation

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC05192A

Reference36 articles.

1. Asymmetric Synthesis of Active Pharmaceutical Ingredients

2. The asymmetric synthesis of (3R)-N-methyl-2-oxo-[1,4′-bipiperidine]-3-acetamide in quantity

3. Optimization and Scale-Up of an Asymmetric Route to the LTB4 Inhibitor Ontazolast

4. Development of an Asymmetric Acetate Aldol Reaction with a Trifluoromethyl Ketone

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