HFIP-promoted Michael reactions: direct para-selective C–H activation of anilines with maleimides

Author:

Li Bang12345,Mao Qi12345,Zhou Jia678910,Liu Feng12345ORCID,Ye Na12345ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences

3. Soochow University

4. Suzhou

5. People's Republic of China

6. Department of Pharmacology and Toxicology

7. Center for Addiction Research

8. University of Texas Medical Branch

9. Galveston

10. USA

Abstract

Diversified 3-aryl succinimide derivatives are efficiently and selectively prepared from various N,N-disubstituted anilines and maleimides under facile metal-free conditions.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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