Biomimetic black phosphorus nanosheets codeliver CDK9 and BRD4 inhibitors for gastric cancer targeted therapy-Reference-Cited by-同舟云学术

Biomimetic black phosphorus nanosheets codeliver CDK9 and BRD4 inhibitors for gastric cancer targeted therapy

Published:2023 Issue:26 Volume:11 Page:6131-6140
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Zhang Zhe¹,Zhang Xiaoyi¹,Ren Zhaojun¹,Wu Xiaoliu²,Qiao Haishi³,Huang Xin³,Zhao Wei⁴^ORCID,Zhang Yuanying²,Lou Kexin¹

Affiliation:

1. Department of Pathology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, P. R. China

2. Department of Molecular Biology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, P. R. China

3. Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 210009, China

4. Department of Pathology, China Pharmaceutical University Nanjing First Hospital, Nanjing 210012, China

Abstract

The combination of BRD4 and CDK9 inhibitors codelivered by M@BP can trigger the significant down-regulation of the MYC oncogene as well as anti-apoptotic genes and induce tumor cell apoptosis by synergistically impairing RNA synthesis in cancer cells.

Funder

Nanjing University of Science and Technology

Jiangsu Cancer Hospital

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D3TB00046J

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