Efficient synthesis of Ibrutinib chiral intermediate in high space-time yield by recombinant E. coli co-expressing alcohol dehydrogenase and glucose dehydrogenase
Author:
Affiliation:
1. School of Chemical and Environmental Engineering
2. Shanghai Institute of Technology
3. Shanghai 201418
4. China
Abstract
A simple and efficient process for the synthesis of optically active (S)-N-boc-3-hydroxy piperidine was developed using the “designer cells” co-expressing alcohol dehydrogenase and glucose dehydrogenase.
Funder
Shanghai Municipal Education Commission
Shanghai Institute of Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/RA/C8RA08100J
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