DNA recognition site of anticancer tinidazole copper(ii) complexes

Author:

Ramírez-Palma Lillian G.1,Castro-Ramírez Rodrigo2,Lozano-Ramos León2,Galindo-Murillo Rodrigo3,Barba-Behrens Norah2ORCID,Cortés-Guzmán Fernando1ORCID

Affiliation:

1. Instituto de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, C. U., México City, 04510, Mexico

2. Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, C. U., México City, 04510, Mexico

3. Department of Medicinal Chemistry, College of Pharmacy, University of Utah, 2000 East 30 South Skaggs 201, Salt Lake City, UT 84112, USA

Abstract

This paper describes the recognition process of tetrahedral [CuII(tnz)2X2] (X = Cl, Br) complexes by a DNA chain, analyzing the specific interaction between the DNA bases and backbone with the metal and the tinidazole (tnz) ligand.

Funder

Consejo Nacional de Ciencia y Tecnología

Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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