Antifibrotic effect of AD-1 on lipopolysaccharide-mediated fibroblast injury in L929 cells and bleomycin-induced pulmonary fibrosis in mice-Reference-Cited by-同舟云学术

Antifibrotic effect of AD-1 on lipopolysaccharide-mediated fibroblast injury in L929 cells and bleomycin-induced pulmonary fibrosis in mice

Published:2022 Issue:14 Volume:13 Page:7650-7665
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Li Tao¹²,Chen Yu¹,Li Yuan¹³,Chen Gang¹^ORCID,Zhao Yuqing²^ORCID,Su Guangyue¹

Affiliation:

1. Shenyang Pharmaceutical University, Shenyang 110016, China

2. Key Laboratory of Nature Medicines of the Changbai Mountain, Ministry of Education, Yanbian University, Yanji 133002, P.R. China

3. Basic medical teaching and Research Department, Liaoning Vocational College of Medicine, Shenyang 110101, China

Abstract

AD-1 has an anti-PF effect and its anti-PF mechanism may be related to its anti-inflammatory and antioxidant effects, and to its capacity to inhibit apoptosis and regulate the TGF-β1/TIMP-1/α-SMA signaling pathway.

Funder

National Natural Science Foundation of China

Department of Science and Technology of Liaoning Province

Shenyang Pharmaceutical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO04212B

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