In vitro and in vivo evaluation of dialkylphosphorylhydrazones against Leishmania chagasi promastigotes and amastigotes-Reference-Cited by-同舟云学术

In vitro and in vivo evaluation of dialkylphosphorylhydrazones against Leishmania chagasi promastigotes and amastigotes

Published:2021 Issue:47 Volume:45 Page:22316-22326
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Matta Carolina Barbosa Brito da¹,Santos-Júnior Paulo Fernando da Silva²,Gonçalves Vinícius Tomaz³,Araújo Morgana Vital de¹,Queiroz Aline Cavalcanti de¹^ORCID,Silva João Kaycke Sarmento¹,Silva João Flávio Monteiro da¹,Padilha Rafael José Ribeiro⁴,Alves Luiz Carlos⁵,Santos Fábio André Brayner dos⁵,Barcellos Lucas Tricarico⁶,Silva-Júnior Edeildo Ferreira da⁶^ORCID,Araújo-Júnior João Xavier de⁶⁷,Costa João Batista Neves da⁶,Sant’Anna Carlos Mauricio R.⁶,Alexandre-Moreira Magna Suzana¹

Affiliation:

1. Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, AL, Brazil

2. Chemistry and Biotechnology Institute, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, Brazil

3. Federal Center for Technology Education Celso Suckow da Fonseca (CEFET/RJ), Itaguaí 20271-110, RJ, Brazil

4. Laboratory of Immunopathology Keizo Asami (LIKA) and Biochemistry Department, Federal University of Pernambuco, Recife 50670-901, PE, Brazil

5. Laboratory of Immunopathology Keizo Asami (LIKA) and Aggeu Magalhães Research Center, CPqAM/FIOCRUZ, Federal University of Pernambuco, Av. Moraes Rego s/n, Cidade Universitária, Recife 50670-420, PE, Brazil

6. Rural Federal University of Rio de Janeiro, Institute of Chemistry, Seropédica 23970-000, RJ, Brazil

7. Laboratory of Medicinal Chemistry, Pharmaceutical Sciences Institute, Federal University of Alagoas, Campus A.C. Simões, Lourival Melo Mota Avenue, Maceió 57072-970, Brazil

Abstract

In our study, two new dialkylphosphorylhydrazones have been designed targeting activity against L. braziliensis and L. amazonensis parasites, and their mechanism of action, as well as their leishmanicidal activity against L. chagasi, was evaluated.

Funder

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NJ/D1NJ03694G

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