Pt(iv) complexes based on cyclohexanediamines and the histone deacetylase inhibitor 2-(2-propynyl)octanoic acid: synthesis, characterization, cell penetration properties and antitumor activity-Reference-Cited by-同舟云学术

Pt(iv) complexes based on cyclohexanediamines and the histone deacetylase inhibitor 2-(2-propynyl)octanoic acid: synthesis, characterization, cell penetration properties and antitumor activity

Published:2021 Issue:13 Volume:50 Page:4663-4672
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Gabano Elisabetta¹²³^ORCID,Rangone Beatrice¹²³,Perin Elena¹²³,Caron Giulia⁴⁵³^ORCID,Ermondi Giuseppe⁴⁵³,Vallaro Maura⁴⁵³,Gandin Valentina⁶⁷³,Marzano Cristina⁶⁷³,Barbanente Alessandra⁸⁹³,Margiotta Nicola⁸⁹³^ORCID,Ravera Mauro¹²³^ORCID

Affiliation:

1. Dipartimento di Scienze e Innovazione Tecnologica

2. Università del Piemonte Orientale

3. Italy

4. Dipartimento di Biotecnologie Molecolari e Scienze per la Salute

5. Università di Torino

6. Dipartimento di Scienze del Farmaco

7. Università di Padova

8. Dipartimento di Chimica

9. Università di Bari

Abstract

Combinations of different cyclohexanediamines and 2-(2-propynyl)octanoate in Pt(iv) complexes resulted in prodrug candidates with promising antiproliferative and in vivo antitumor activity.

Funder

Università degli Studi del Piemonte Orientale

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT04135A

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