Mechanistic insights into the C<sub>55</sub>-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures-Reference-Cited by-同舟云学术

Mechanistic insights into the C₅₅-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures

Published:2022 Issue:10 Volume:13 Page:2985-2991
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wood Thomas M.¹²^ORCID,Zeronian Matthieu R.³^ORCID,Buijs Ned¹,Bertheussen Kristine¹,Abedian Hanieh K.¹,Johnson Aidan V.¹,Pearce Nicholas M.³^ORCID,Lutz Martin³,Kemmink Johan⁴,Seirsma Tjalling⁵,Hamoen Leendert W.⁵,Janssen Bert J. C.³^ORCID,Martin Nathaniel I.¹^ORCID

Affiliation:

1. Biological Chemistry Group, Institute of Biology Leiden, Leiden University, Sylviusweg 72, 2333 BE Leiden, The Netherlands

2. Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands

3. Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

4. Faculty of Science and Engineering, University of Groningen, 9747 AG Groningen, The Netherlands

5. Bacterial Cell Biology and Physiology Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands

Abstract

Structural and mechanistic studies give new insights into calcium-dependent lipopeptide antibiotics that target C55-P.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC07190D

Reference24 articles.