Facile synthesis of quinoxaline annulated perfluoroalkylated benzoazepine derivatives
Author:
Affiliation:
1. Department of Chemistry
2. Innovative Drug Research Center
3. Shanghai University
4. Shanghai 200444
5. P. R. China
6. Laboratory for Microstructures
7. Instrumental Analysis and Research Center of Shanghai University
Abstract
Perfluoroalkylated benzoazepinoquinoxalines 3 were synthesized by a consecutive intermolecular Michael addition and intramolecular cyclization from 3-(2-aminophenyl)quinoxalin-2(1H)-ones 1 and methyl perfluoroalk-2-ynoates 2 in good yields.
Funder
National Natural Science Foundation of China
Shanghai Municipal Education Commission
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA22727A
Reference30 articles.
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2. Quinoxaline, its derivatives and applications: A State of the Art review
3. Hypolipidemic Activity of 6-Substituted 6, 7-Dihydro-5H-dibenz[c,e]azepine and the effects of 6, 7-dihydro-5H-dibenz[c,e]azepine on Lipid Metabolism of Rodents
4. Tricyclic epines. Novel (E)- and (Z)-11H-dibenz[b,e]azepines as potential central nervous system agents. Variation of the basic side chain
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