An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs-Reference-Cited by-同舟云学术

An “occlusive thrombosis-on-a-chip” microfluidic device for investigating the effect of anti-thrombotic drugs

Published:2021 Issue:21 Volume:21 Page:4104-4117
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Berry Jess¹,Peaudecerf François J.²^ORCID,Masters Nicole A.³,Neeves Keith B.³^ORCID,Goldstein Raymond E.⁴,Harper Matthew T.¹

Affiliation:

1. Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK

2. Department of Civil, Environmental, and Geomatic Engineering, ETH Zürich, 8093 Zürich, Switzerland

3. Department of Bioengineering, Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplant, Hemophilia and Thrombosis Center, University of Colorado Denver|Anschutz Medical Campus, Aurora, CO, USA

4. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, UK

Abstract

This occlusive thrombosis-on-a-chip microfluidic device can be used to test antithrombotic drugs. The device uses an on-chip chaotic mixer to introduce EDTA and quench downstream coagulation, essential for reliable determination of occlusion time.

Funder

National Centre for the Replacement, Refinement and Reduction of Animals in Research

British Heart Foundation

Wellcome Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00347J

Reference81 articles.

1. Arterial thrombosis—insidious, unpredictable and deadly