Single-molecule level dynamic observation of disassembly of the apo-ferritin cage in solution-Reference-Cited by-同舟云学术

Single-molecule level dynamic observation of disassembly of the apo-ferritin cage in solution

Published:2020 Issue:33 Volume:22 Page:18562-18572
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Maity Basudev¹²³⁴,Li Zhipeng¹²³⁴⁵,Niwase Kento¹²³⁴,Ganser Christian⁶⁷⁸⁴,Furuta Tadaomi¹²³⁴^ORCID,Uchihashi Takayuki⁶⁷⁸⁴⁹^ORCID,Lu Diannan⁵¹⁰¹¹¹²¹³,Ueno Takafumi¹²³⁴^ORCID

Affiliation:

1. Department of Life Science and Technology

2. Tokyo Institute of Technology

3. Yokohama 226-8501

4. Japan

5. Ministry of Education Key Laboratory of Industrial Biocatalysis

6. Exploratory Research Center on Life and Living Systems (ExCELLS)

7. National Institutes of Natural Sciences

8. Okazaki

9. Department of Physics

10. Department of Chemical Engineering

11. Tsinghua University

12. Beijing 100084

13. China

Abstract

The 24-mer iron-storage protein, ferritin cage assembly plays important role in nanomaterials synthesis and drug delivery. Herein we explored the disassembly process of the cage by high-speed AFM in combination with all-atom MD simulations.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CP/D0CP02069A

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