Insightful vibrational imaging study on the hydration mechanism of carbamazepine

Author:

Fateixa Sara1ORCID,Nogueira Helena I. S.1ORCID,Paixão José A.2ORCID,Fausto Rui3ORCID,Trindade Tito1ORCID

Affiliation:

1. Department of Chemistry and CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal

2. CFisUC, Department of Physics, University of Coimbra, P-3004-516 Coimbra, Portugal

3. CQC-IMS, Department of Chemistry, University of Coimbra, P-3004-535 Coimbra, Portugal

Abstract

The hydration mechanism of anhydrous carbamazepine, under different ambient conditions, is investigated here for the first time by complementary vibrational imaging techniques: confocal Raman microscopy and infrared imaging.

Funder

Fundação para a Ciência e a Tecnologia

Centro de Investigação em Materiais Cerâmicos e Compósitos

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference39 articles.

1. D. J. W.Grant , in Polymorphism in pharmaceutical solids , ed. H. G. Brittain , Marcel Dekker, Inc. , New York , 1999 , vol. 95, pp. 1–35

2. J.Bernstein , Polymorphism in molecular crystals , Oxford Science Publications , Oxford , 2002

3. Polymorphism and Solvatomorphism 2005

4. Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt Extrusion

5. Probing Pseudopolymorphic Transitions in Pharmaceutical Solids using Raman Spectroscopy: Hydration and Dehydration of Theophylline

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