DNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium(ii) terpyridine complexes

Author:

Lazić Dejan12345,Arsenijević Aleksandar12345,Puchta Ralph678910,Bugarčić Živadin D.1112345,Rilak Ana1112345

Affiliation:

1. Faculty of Medicine

2. Centre for Molecular Medicine and Stem Cell Research

3. University of Kragujevac

4. 34000 Kragujevac

5. Serbia

6. Institute for Inorganic Chemistry

7. Department of Chemistry and Pharmacy

8. University of Erlangen-Nürnberg

9. 91058 Erlangen

10. Germany

11. Department of Chemistry

12. Faculty of Science

Abstract

UV-Vis spectroscopy studies, viscosity measurements and competitive binding studies with EB have revealed the ability of the complexes to bind to CT DNA covalently through N7 of guanine residues and non-covalently through intercalation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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