Capture of RNA G-quadruplex structures using an l-RNA aptamer

Author:

Lam Sin Yu1ORCID,Umar Mubarak Ishaq12,Zhao Haizhou1,Zhao Jieyu1,Kwok Chun Kit13ORCID

Affiliation:

1. Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon Tong, Hong Kong SAR 999077, China

2. RNA Molecular Biology Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD, USA

3. Shenzhen Research Institute of City University of Hong Kong, Shenzhen, China

Abstract

RNA G-quadruplexes (rG4s) play crucial roles in fundamental biological processes. We report a novel pulldown assay for rG4s using an l-Apt.4-1c aptamer and compare its performance with the BioTASQ v.1 ligand.

Funder

National Natural Science Foundation of China

Research Grants Council, University Grants Committee

State Key Laboratory in Marine Pollution

City University of Hong Kong

Publisher

Royal Society of Chemistry (RSC)

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