Rational design of a hexapeptide hydrogelator for controlled-release drug delivery

Author:

Bibian Mathieu1234,Mangelschots Jeroen1234,Gardiner James567,Waddington Lynne567,Diaz Acevedo Maria M.8234,De Geest Bruno G.910114,Van Mele Bruno8234,Madder Annemieke1210134,Hoogenboom Richard141510134,Ballet Steven1234

Affiliation:

1. Research Group of Organic Chemistry

2. Vrije Universiteit Brussel

3. Brussels

4. Belgium

5. Materials Science & Engineering

6. Commonwealth Scientific and Industrial Organization

7. Australia

8. Physical Chemistry and Polymer Science

9. Department of Pharmaceutics

10. Ghent University

11. Ghent

12. Organic and Biomimetic Chemistry Research Group

13. 9000 Ghent

14. Supramolecular Chemistry Group

15. Department of Organic Chemistry

Abstract

The amphiphilic peptide sequence H-Phe-Glu-Phe-Gln-Phe-Lys-OH (MBG-1) is developed as a novel hydrogelator for controlled-drug release, which is the smallest tunable ionic self-complementary hydrogelating peptide reported to date making it attractive for larger scale preparation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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