A new oxime synthesized from <i>Senecio nutans</i> SCh. Bip (chachacoma) reduces calcium influx in the vascular contractile response in rat aorta-Reference-Cited by-同舟云学术

A new oxime synthesized from Senecio nutans SCh. Bip (chachacoma) reduces calcium influx in the vascular contractile response in rat aorta

Published:2024 Issue:14 Volume:14 Page:9933-9942
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Palacios Javier¹^ORCID,Asunción-Alvarez Daniel¹^ORCID,Aravena Diego¹,Chiong Mario²^ORCID,Catalán Marcelo A.³^ORCID,Parra Claudio⁴^ORCID,Cifuentes Fredi⁵^ORCID,Paredes Adrián⁶^ORCID

Affiliation:

1. Laboratorio de Bioquímica Aplicada, Facultad de Ciencias de la Salud, Universidad Arturo Prat, Iquique 1110939, Chile

2. Universidad de Chile, Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas, Santiago, Chile

3. Instituto de Fisiología, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5090000, Chile

4. Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Concepción, Edmundo Larenas 129, Concepción 4070371, Chile

5. Laboratorio de Fisiología Experimental (EPhyL), Instituto Antofagasta (IA), Universidad de Antofagasta, Antofagasta 1271155, Chile

6. Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Antofagasta 1271155, Chile

Abstract

The Sn–I metabolite decreases the contractile response to KCl or phenylephrine (PE) mainly by blocking Ca2+ entry through voltage-gated Ca2+ channel (VGCC).

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01058B

Reference24 articles.

1. Anti-hypertensive Herbs and their Mechanisms of Action: Part I

2. Antioxidant activity of nine medicinal plants with commercial potential

3. Hypotensive and antihypertensive effects of a hydroalcoholic extract from Senecio nutans Sch. Bip. (Compositae) in mice: Chronotropic and negative inotropic effect, a nifedipine-like action

4. Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms

5. Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats