Study on alterations of physiological functions in aged constipation rats with fluid-deficiency based on metabonomic and microbiology analysis

Author:

Liu Deliang12345,Li Tiantian6234,Zheng Haihui5784,Yin Xiquan9810,Chen Mingyi5784,Liao Ziqong5784,Hu Minghua9810,Luo Zhen9810,Lu Biyu111284,Li Yuan111284,Liao Qiongfeng111284,Xie Zhiyong5784ORCID,Wu Fuhai1234

Affiliation:

1. School of Public Health

2. Guangdong Pharmaceutical University

3. Guangzhou 51006

4. P. R. China

5. School of Pharmaceutical Sciences (Shenzhen)

6. School of Pharmacy

7. Sun Yat-sen University

8. Guangzhou

9. Infinitus (China) Company Ltd

10. China

11. School of Chinese Materia Medica

12. Guangzhou University of Chinese Medicine

Abstract

To clarify how constipation interferes with the normal physiological function of organisms,1H NMR profiles combined with PCR-DGGE and 16s rRNA gene sequencing were used to investigate the relationship among constipation, metabolite and gut microbiota.

Funder

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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