Identification of the first selective bioluminescent probe for real-time monitoring of carboxylesterase 2 <i>in vitro</i> and <i>in vivo</i>-Reference-Cited by-同舟云学术

Identification of the first selective bioluminescent probe for real-time monitoring of carboxylesterase 2 in vitro and in vivo

Published:2024 Issue:2 Volume:149 Page:418-425
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Chen Yuhao¹²,Zhao Tiantian¹,Miao Zhuang¹^ORCID,Huang Tianguang¹,Chen Meiyuan¹,Zhao Yi¹,Hai Ao¹,Qi Qingrong²,Feng Ping³,Li Minyong⁴^ORCID,Ke Bowen¹

Affiliation:

1. Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

2. West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, China

3. Institute of Clinical Trials, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

4. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012, China

Abstract

This study identified the first selective bioluminescent probe (CBP 1) for CES2 monitoring. CBP 1 exhibited good capability for real-time detection of CES2 and its dynamic fluctuations with high sensitivity, high specificity and rapid reactivity.

Funder

National Natural Science Foundation of China

West China Hospital, Sichuan University

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D3AN01745A

Reference30 articles.

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5. Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs