Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited-Reference-Cited by-同舟云学术

Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited

Published:2017 Issue:35 Volume:15 Page:7456-7473
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Adriaenssens Y.¹²³⁴,Jiménez Fernández D.⁵⁶⁷⁴⁸^ORCID,Vande Walle L.⁵⁶⁷⁴⁸,Elvas F.¹²³⁴^ORCID,Joossens J.¹²³⁴,Lambeir A.⁹²³⁴,Augustyns K.¹²³⁴^ORCID,Lamkanfi M.⁵⁶⁷⁴⁸,Van der Veken P.¹²³⁴^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry

2. University of Antwerp

3. B-2610 Wilrijk

4. Belgium

5. Center for Inflammation Research

6. VIB

7. B-9052 Ghent

8. Department of Internal Medicine

9. Laboratory of Medical Biochemistry

Abstract

Acylsulfonamides are efficient carboxylate isosteres for caspase inhibitors. In inhibitors with an aldehyde warhead, they serve as prodrug-type precursors of the carboxylate-containing compounds.

Funder

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01403A

Reference49 articles.

1. Many cuts to ruin: a comprehensive update of caspase substrates

2. The protein structures that shape caspase activity, specificity, activation and inhibition

3. New Approaches and Therapeutics Targeting Apoptosis in Disease