Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors-Reference-Cited by-同舟云学术

Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors

Published:2020 Issue:5 Volume:11 Page:559-568
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Muller J.¹²³⁴^ORCID,Cardey B.⁵²³⁴^ORCID,Zedet A.¹²³⁴,Desingle C.¹²³⁴,Grzybowski M.⁶⁷⁸,Pomper P.⁶⁷⁸,Foley S.⁵²³⁴,Harakat D.⁹¹⁰¹¹⁴,Ramseyer C.⁵²³⁴,Girard C.¹²³⁴,Pudlo M.¹²³⁴^ORCID

Affiliation:

1. PEPITE EA4267

2. Univ. Bourgogne Franche-Comté

3. F-25000 Besançon

4. France

5. Laboratoire Chrono-environnement (UMR CNRS 6249)

6. OncoArendi Therapeutics

7. PL02089 Warsaw

8. Poland

9. Institut de Chimie Moléculaire de Reims (UMR CNRS 7312)

10. Univ. Reims Champagne Ardenne

11. F-51000 Reims

Abstract

A quantum chemistry guided optimisation (leading to piceatannol analogue 3t) with a good understanding of the catechol binding mode to the bimanganese cluster of arginase.

Funder

Conseil régional de Bourgogne-Franche-Comté

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00011F

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3. The Emerging Role of Arginase in Endothelial Dysfunction in Diabetes

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