Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N′-thiazol-2-yl-hydrazines-Reference-Cited by-同舟云学术

Dual-target inhibitors of mycobacterial aminoacyl-tRNA synthetases among N-benzylidene-N′-thiazol-2-yl-hydrazines

Published:2019 Issue:12 Volume:10 Page:2161-2169
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Kovalenko Oksana P.¹²³⁴⁵^ORCID,Volynets Galyna P.⁶²³⁴⁵^ORCID,Rybak Mariia Yu.¹²³⁴⁵^ORCID,Starosyla Sergiy A.⁶²³⁴⁵,Gudzera Olga I.¹²³⁴⁵,Lukashov Sergiy S.⁶²³⁴⁵,Bdzhola Volodymyr G.⁶²³⁴⁵,Yarmoluk Sergiy M.⁶²³⁴⁵,Boshoff Helena I.⁷⁸⁹¹⁰¹¹,Tukalo Michael A.¹²³⁴⁵

Affiliation:

1. Department of Protein Synthesis Enzymology

2. Institute of Molecular Biology and Genetics

3. The NAS of Ukraine

4. 03143 Kyiv

5. Ukraine

6. Department of Medicinal Chemistry

7. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology

8. National Institute of Allergy and Infectious Disease

9. National Institute of Health

10. Bethesda

11. USA

Abstract

A screen of 37 compounds identified four inhibitors that exhibited dual on-target activity against Mycobacterium tuberculosis aminoacyl-tRNA synthetases.

Funder

Science and Technology Center in Ukraine

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C9MD00347A

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