Liposome manufacturing under continuous flow conditions: towards a fully integrated set-up with in-line control of critical quality attributes

Author:

Sheybanifard Maryam1ORCID,Guerzoni Luis P. B.2,Omidinia-Anarkoli Abdolrahman23,De Laporte Laura234ORCID,Buyel Johannes567,Besseling Rut8ORCID,Damen Michiel8,Gerich Ad8,Lammers Twan1ORCID,Metselaar Josbert M.1

Affiliation:

1. Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Uniklinik RWTH Aachen and Helmholtz Institute for Biomedical Engineering, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany

2. DWI Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52074 Aachen, Germany

3. Institute of Applied Medical Engineering, RWTH University, Pauwelsstraße 20, 52074 Aachen, Germany

4. Institute for Technical and Macromolecular Chemistry, RWTH Aachen, Worringerweg 1-2, 52074 Aachen, Germany

5. Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Forckenbeckstrasse 6, 52074 Aachen, Germany

6. Institute for Molecular Biotechnology, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany

7. Institute of Bioprocess Science and Engineering, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, A-1190 Vienna, Austria

8. InProcess-LSP, Kloosterstraat 9, 5349 AB Oss, The Netherlands

Abstract

Schematic view of the ultimate design of the continuous flow manufacturing production line; from particle formation and in-line control of critical quality attributes to the filling.

Funder

Deutsche Forschungsgemeinschaft

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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