Ultrahigh SERS activity of the TiO2@Ag nanostructure leveraged for accurately detecting CTCs in peripheral blood

Author:

Xu Yanping123,Zhang Dinghu3,Lin Jie24,Wu Xiaoxia23,Xu Xiawei24,Akakuru Ozioma Udochukwu24ORCID,Zhang Hao24,Zhang Zhewei3,Xie Yujiao24,Wu Aiguo24ORCID,Shao Guoliang3

Affiliation:

1. Second clinical college, Zhejiang Chinese Medical University, Hang Zhou 310053, China

2. Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices & Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, 1219 ZhongGuan West Road, Ningbo 315201, China

3. Department of Interventional Radiology, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China

4. Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, P.R. China

Abstract

Accurately recognizing CTCs in peripheral blood based on the TiO2@Ag–R6G–rBSA–FA SERS bioprobe is carefully verified by in situ immunofluorescence staining experiments, which directly supports the CTC detection accuracy of the SERS strategy.

Funder

National Natural Science Foundation of China

Science and Technology Innovation 2025 Major Project of Ningbo

3315 Innovation Team in Ningbo City

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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