Development of a continuous flow synthesis of FGIN-1-27 enabled by in-line 19F NMR analyses and optimization algorithms-Reference-Cited by-同舟云学术

Development of a continuous flow synthesis of FGIN-1-27 enabled by in-line 19F NMR analyses and optimization algorithms

Published:2021 Issue:10 Volume:6 Page:1983-1992
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Vasudevan N.¹,Aka Ehu C.¹,Barré Elvina¹,Wimmer Eric²,Cortés-Borda Daniel³,Giraudeau Patrick¹^ORCID,Farjon Jonathan¹^ORCID,Rodriguez-Zubiri Mireia¹,Felpin François-Xavier¹^ORCID

Affiliation:

1. Université de Nantes, CNRS, CEISAM UMR 6230, 2 rue de la Houssinière, 44322 Nantes, France

2. Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France

3. Universidad del Atlántico, Facultad de ciencias básicas, Carrera 30 # 8-49, Puerto Colombia, Atlántico, Colombia

Abstract

A continuous flow synthesis of FGIN-1-27 has been developed using enabling technologies such as real-time in-line benchtop 19F NMR analysis and an optimization algorithm.

Funder

Université de Nantes

Centre National de la Recherche Scientifique

Conseil Régional des Pays de la Loire

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RE/D1RE00220A

Reference49 articles.

1. FGIN-1-27, an agonist at translocator protein 18 kDa (TSPO), produces anti-anxiety and anti-panic effects in non-mammalian models

2. In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters

3. FGIN-1-27 Inhibits Melanogenesis by Regulating Protein Kinase A/cAMP-Responsive Element-Binding, Protein Kinase C-β, and Mitogen-Activated Protein Kinase Pathways

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1. Autonomous reaction self-optimization using in-line high-field NMR spectroscopy;Reaction Chemistry & Engineering;2024

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3. Will the next generation of chemical plants be in miniaturized flow reactors?;Lab on a Chip;2023

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