The deformation of cancer cells through narrow micropores holds the potential to regulate genes that impact cancer malignancy

Author:

Choi Jong Seob123,Lee Su Han4,Park Hye Bin4,Chun Changho1,Kim Yeseul5,Kim Kyung Hoon6,Weon Byung Mook5ORCID,Kim Deok-Ho12ORCID,Kim Hyung Jin4,Lee Jung Hyun78ORCID

Affiliation:

1. Department of Bioengineering, University of Washington, 850 Republican Street, Seattle, WA 98109, USA

2. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA

3. Division of Advanced Materials Engineering, Kongju National University, Budaedong 275, Seobuk-gu, Cheonan-si, Chungnam, 31080, South Korea

4. Digital Health Care Research Center, Gumi Electronics and Information Technology Research Institute (GERI), 350-27, Gumidaero, Gumi, Gyeongbuk 39253, South Korea

5. Soft Matter Physics Laboratory, School of Advanced Materials Science and Engineering, SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon 16419, South Korea

6. Department of Bioengineering, University of Washington, 3720 15th Ave NE, Seattle, WA 98195, USA

7. Division of Dermatology, Department of Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA

8. Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA

Abstract

Proposal for an in vitro research method to understand the establishment of a defense system that enables cancer cells to efficiently attack due to cancer deformation.

Funder

Elsa U. Pardee Foundation

Human Frontier Science Program

Ministry of Science, ICT and Future Planning

Ministry of Trade, Industry and Energy

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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