Structure–activity relationship study for design of highly active covalent peroxidase-mimicking DNAzyme
Author:
Affiliation:
1. Department of Chemistry
2. Lomonosov Moscow State University
3. Moscow 119991
4. Russia
5. Belozersky Institute of Physical and Chemical Biology
Abstract
We synthesized a series of conjugates of hemin and its aptamer EAD2, named covalent peroxidase-mimicking DNAzymes (PMDNAzymes), varying the length, rigidity and 5′-/3′-position of the linker between the oligonucleotide and hemin.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA03167B
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