Characterizing the free-energy landscapes of DNA origamis-Reference-Cited by-同舟云学术

Characterizing the free-energy landscapes of DNA origamis

Published:2022 Issue:7 Volume:14 Page:2638-2648
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Wong Chak Kui¹^ORCID,Tang Chuyan¹,Schreck John S.²^ORCID,Doye Jonathan P. K.¹^ORCID

Affiliation:

1. Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, UK

2. National Center for Atmospheric Research, Computational and Information Systems Laboratory, 850 Table Mesa Drive, Boulder, CO 80305, USA

Abstract

We show how coarse-grained modelling combined with umbrella sampling using distance-based order parameters can be applied to compute the free-energy landscapes associated with mechanical deformations of large DNA nanostructures.

Funder

Croucher Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NR/D1NR05716B

Reference73 articles.

1. DNA Origami: Scaffolds for Creating Higher Order Structures

2. DNA nanotechnology

3. Folding DNA to create nanoscale shapes and patterns

4. DNA origami

5. Cryo-EM structure of a 3D DNA-origami object

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