Modulation of DNA–polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics-Reference-Cited by-同舟云学术

Modulation of DNA–polyamide interaction by β-alanine substitutions: a study of positional effects on binding affinity, kinetics and thermodynamics

Published:2014 Issue:38 Volume:12 Page:7523-7536
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Shuo¹²³⁴,Aston Karl⁵⁶⁷⁸,Koeller Kevin J.⁵⁶⁷⁸,Harris G. Davis⁵⁶⁷⁸,Rath Nigam P.⁵⁶⁷⁸,Bashkin James K.⁵⁶⁷⁸,Wilson W. David¹²³⁴

Affiliation:

1. Department of Chemistry

2. Center for Diagnostics and Therapeutics

3. Georgia State University

4. Atlanta, USA

5. Department of Chemistry & Biochemistry

6. Center for Nanoscience

7. University of Missouri-St. Louis

8. St. Louis, USA

Abstract

The substitution of an internal pyrrole with a β motif has large and diverse effects on hairpin polyamide-DNA binding affinity, kinetics and binding orientation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01456A

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