The functional regulatory details of ERK2 in complex with RSK1: an in silico insight

Author:

Jafari Sepideh12345,Farsani Farzaneh Mohamadi12345,Ganji Maziar67895,Ganjalikhany Mohamad Reza12345ORCID

Affiliation:

1. Department of Cell and Molecular Biology

2. Faculty of Biological Science and Technology

3. University of Isfahan

4. Isfahan

5. Iran

6. Department of Medical Genetics

7. School of Medicine

8. Shahid Beheshti University of Medical Sciences

9. Tehran

Abstract

DFG, αC-helix orientation regarding the active site position and distance between K54 and Glu71 in the active and inactive states of ERK2.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference46 articles.

1. MAP kinase pathways

2. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

3. Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein Kinase 5

4. Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

5. K.Duda and M.Frödin , Stimuli that Activate MSK in Cells and the Molecular Mechanism of Activation, in Madame Curie Bioscience Database [Internet] , Landes Bioscience , Austin (TX) , 2000–2013 , Available from: https://www.ncbi.nlm.nih.gov/books/NBK91435/

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