A multiplexed ion-exchange membrane-based miRNA (MIX·miR) detection platform for rapid diagnosis of myocardial infarction-Reference-Cited by-同舟云学术

A multiplexed ion-exchange membrane-based miRNA (MIX·miR) detection platform for rapid diagnosis of myocardial infarction

Published:2021 Issue:20 Volume:21 Page:3876-3887
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Ren Xiang¹^ORCID,Ellis Bradley W.¹,Ronan George¹,Blood Stuart Ryan²,DeShetler Cameron²,Senapati Satyajyoti²,March Keith L.³,Handberg Eileen³,Anderson David³,Pepine Carl³,Chang Hsueh-Chia¹²^ORCID,Zorlutuna Pinar¹²^ORCID

Affiliation:

1. Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA

2. Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA

3. Division of Cardiology, Department of Medicine in the College of Medicine, University of Florida, Gainesville, FL 32611, USA

Abstract

This work reports a multiplexed ion-exchange membrane-based miRNA sensor, namely MIX·miR, for detection of multiple specific cardiac-associated exosomal miRNA markers in clinical plasma samples with concentrations as low as 1 pM.

Funder

National Heart, Lung, and Blood Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00685A

Reference57 articles.

1. Myocardial ischemia-reperfusion injury: a neglected therapeutic target

2. Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction

Biomarkers in acute myocardial infarction: current perspectives